承担科研项目情况 |
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项目名称 |
项目编号 |
项目类别 |
经费 |
起止时间 |
承担人 |
|
氢分子改善代谢综合征所致高密度脂蛋白功能损害的分子机制 |
81770855 |
国家自然科学基金面上项目 |
56万 |
2018.01-2021.12 |
秦树存
|
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氢生物学效应靶向氧化应激代谢疾病关键技术和药效机制的研究 |
2019QL010 |
山东第一医科大学 具有潜力科研方向 |
1000万 |
2019.01-2023.12 |
秦树存 |
|
氢分子调控巨噬细胞炎性极化和胆固醇代谢转运的分子机制 |
81670422 |
国家自然科学基金面上项目 |
57万 |
2017.01-2020.12 |
宋国华 |
|
氢分子影响动脉粥样斑块稳定性及其巨噬细胞内质网应激凋亡途径的分子机制 |
81200216 |
国家自然科学基金青年基金 |
23万 |
2013.01-2015.12 |
宋国华 |
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获奖情况 |
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获奖成果（项目）名称 |
奖励等级 |
授奖单位 |
获奖时间 |
获奖者姓名 |
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氢分子对多器官组织氧化应激相关损伤的保护作用 |
山东省科技进步二等奖 |
山东省人民政府 |
2014 |
秦树存，孙学军，宋国华，蔡建美，赵晓民，孙强，宗传龙，田华，王云 |
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氢分子对多器官组织氧化应激相关损伤的保护作用 |
山东高等学校优秀科研成果奖一等奖 |
山东省教育厅 |
2013 |
秦树存、宋国华、赵晓民、宗传龙、田华、王云 |
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授权专利情况 |
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专利名称 |
授权国 |
专利号 |
类型 |
年份 |
专利权人（注明位次） |
|
氢气饱和生理盐水的应用 |
中国 |
201510335932.6 |
发明专利 |
2018年授权 |
宋国华，秦树存，于杨 |
|
一种用于研究动物吸入氢气的吸氢装置及其系统 |
中国 |
201921705959.X |
实用新型 |
2020年授权 |
秦树存，薛俊莉，刘伯言，陈微，常强 |
|
一种氢气细胞培养装置及细胞培养系统 |
中国 |
201921595117.3 |
实用新型 |
2020年授权 |
秦树存，刘伯言，薛俊莉，常强 |
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发表文章
Liu, B., Xue, J., Zhang, M., Wang, M., Ma, T., Zhao, M. I. N., … Qin, S. (2020). Hydrogen inhalation alleviates nonalcoholic fatty liver disease in metabolic syndrome rats. Molecular Medicine Reports, DOI: 10.3892/mmr.2020.11364
Tao, G., Song, G., & Qin, S. (2019). Molecular hydrogen: Current knowledge on mechanism in alleviating free radical damage and diseases. Acta Biochimica et Biophysica Sinica, 51(12), 1189–1197.
Song, G., Lin, Q., Zhao, H., Liu, M., Ye, F., Sun, Y., … Qin, S. (2015). Hydrogen activates atp-binding cassette transporter a1-dependent efflux ex vivo and improves high-density lipoprotein function in patients with hypercholesterolemia: A double-blinded, randomized, and placebo-controlled trial. Journal of Clinical Endocrinology and Metabolism, 100(7), 2724–2733.
Jing, L., Wang, Y., Zhao, X. M., Zhao, B., Han, J. J., Qin, S. C., & Sun, X. J. (2015). Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats. Heart,Lung and Circulation, 24(6), 602–610.
Song, G., Zong, C., Zhang, Z., Yu, Y., Yao, S., Jiao, P., … Qin, S. (2015). Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice. Free Radical Biology and Medicine, 87, 58–68.
Zong, C., Song, G., Yao, S., Guo, S., Yu, Y., Yang, N., … Qin, S. (2015). Cigarette smoke exposure impairs reverse cholesterol transport which can be minimized by treatment of hydrogen-saturated saline. Lipids in Health and Disease, 14, 159.
Song, G., Li, M., Sang, H., Zhang, L., Li, X., Yao, S., … Qin, S. (2013). Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. Journal of Lipid Research, 54(7), 1884–1893.
Zong, C., Song, G., Yao, S., Li, L., Yu, Y., Feng, L., … Qin, S. (2012). Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters. Metabolism: Clinical and Experimental, 61(6), 794–800.
Song, G., Tian, H., Qin, S., Sun, X., Yao, S., Zong, C., … Wang, X. (2012). Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice. Atherosclerosis, 221(1), 55–65.
Wei, L., Ge, L., Qin, S., Shi, Y., Du, C., Du, H., … Sun, X. (2012). Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injuryin guinea pig. Experimental Eye Research, 94(1), 117–127.
Wang, Y., Jing, L., Zhao, X.-M., Han, J.-J., Xia, Z.-L., Qin, S.-C., … Sun, X.-J. (2011). Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model. Respiratory Research, 12(1), 26.
Song, G., Tian, H., Liu, J., Zhang, H., Sun, X., & Qin, S. (2011). H2 inhibits TNF-α-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor κB activation in endothelial cells. Biotechnology Letters, 33(9), 1715–1722.
刘伯言, 秦树存. (2018). 氢分子供体种类及其在体内代谢动力学特点. 生理学报, 71(2), 371–377.
陈印忠,宋国华,贾庆卫,吴云,秦树存. (2016). 新型抗氧化气体分子氢的临床应用研究及其可能的作用机制. 中华老年心脑血管病杂志, 18(01):97-100.
