一、基本情况：

宋文刚，男，1964年2月生，二级岗位教授，全国优秀教师，享受国务院颁发政府特殊津贴人员，山东省教学名师，山东省优秀研究生指导教师，山东省高校十大师德标兵提名奖，山东省卫生系统中青年重点科技人才，山东省免疫学会基础免疫学专业委员会副主任委员，学校免疫学教研室主任。

    山东省《医学免疫学》优秀教学团队和精品课程的主持人，首位获山东省教学成果奖二等奖、山东省研究生教育省级教学成果奖三等奖和山东省高等学校实验教学与实验技术成果奖二等奖，山东省优秀硕士学位论文指导教师。

在科学研究、技术推广等方面，主要的研究方向是从事树突状细胞的分化发育的研究工作和原料血浆筛选及凝血因子分离过程效价衰减分析研究，国家973计划项目《肠道黏膜免疫系统发育及其相关疾病的调控机制》学术骨干，主持国家科技重大专项—“重大新药创制”子课题，主持国家自然科学基金项目4项。首位获山东省科学技术奖三等奖和山东省高等学校优秀科研成果奖一等奖。在Cellular Molecular Immunology 、Journal of Reproductive Immunology、Oncotarget、Nature Immunology等杂志上发表论文。

二、发表文章：

1. Wang Q, He H, Chen DW, Wang C, Xu YP, Song WG*. Hepatic stroma-educated regulatory DCs suppress CD8+T cell proliferation in mice. Oncotarget, 2017 Jun 13. doi: 10.18632/oncotarget.18459. [Epub ahead of print]

 2. Zhao K, Yang T, Sun MM, Zhang W, An Y, Chen G, Jin L, Shang QH*, Song WG*. IP-10 Expression in Patients with Chronic HBV Infection and Its Ability to Predict the Decrease in HBsAg Levels after Treatment with Entecavir. Mol Cells. 2017;40(6):418-425.

3. Ge L, Wei LH, Du CQ, Song GH, Xue YZ, Shi HS, Yang M, Yin XX, Li RT, Wang XE, Wang Z*, Song WG*. Hydrogen-rich saline attenu-ates spinal cord hemisection-induced testicular injury in rats. Oncotarget, 2017;8(26):42314-42331.

4. Li YL, Liu XY, Duan W, Tian H, Zhu GM, He H, Yao ST, Yi SY, Song WG*, Tang H*. Batf3-dependent CD8α+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages. Ebiomedicine, 2017, 18: 188-198.

5. Miao Z, Li S, Wang L,Song W, Zhou Y.Antimicrobial Resistance and Molecular Epidemiology of ESBL-Producing Escherichia coli Isolated from Outpatients in Town Hospitals of Shandong Province, China.Front Microbiol.2017;8:63.

6. He H, Geng TT, Chen PY, Wang MX, Hu JX, Kang L, Song WG*, Tang H*. NK cells promote neutrophil recruitment in the brain during sepsis-induced neuroinflammation. Scientific Reports, 2016, 6:27711.

7. Xu YP, Liu Y, Yang CQ, Kang L, Wang MX, Hu JX, He H, Song WG*, Tang H*. Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4+ T-cell responses. Immunology, 2016, 149: 157-171.

8. Hu JX, He H, Yang ZG, Zhu GM, Kang L, Jing XL, Lu H, Song WG, Bai B, Tang H.Programmed death ligand-1 on microglia regulates Th1 differentiation via nitric oxide in experimental autoimmune encephalomyelitis. Neuroscience Bulletin, 2016, 32(1): 70-82.

9. Wang SL, Zhao G, Zhu W, Dong XM, Liu T, Li YY, Song WG*, Wang YQ*. Herpes simplex virus-1 infection or Simian virus 40-mediated immortalization of corneal cells causes permanent translocation of NLRP3 to the nuclei. Int J Ophthalmol. 2015, 8(1): 46-51.

10. Li S, Zhou YF, Zhao YX, Li WB, Song WG, Miao ZM. Avian influenza H9N2 seroprevalence among pig population and pig farm staff in Shandong, China. Virology Journal, 2015, 12: 34.

11. Li S, Song WG, Zhou YF, Tang YJ, Gao YX, Miao ZM. Spread of extended-spectrum beta-lactamase-producing Escherichia coli from a swine farm to the receiving river. Environ Sci Pollut Res, 2015, 22: 13033-13037.

12. Zhang H, Li H, Li Y, Zou Y, Dong X, Song W,Jia C, Li S, Xi H, Liu D, Wang Y. IL-17 plays a central role in initiating experimental Candida albicans infection in mouse corneas.Eur J Immunol. 2013 ,43(10):2671-82.

13. Zou Y, Zhang H, Li H, Chen H, Song WG*, Wang Y*. Strain-dependent production of interleukin-17/interferon-γ and matrix re-modeling-associated genes in experimental Candida albicans keratitis. Mol Vis. 2012; 18:1215-25.

14. Zhong K^#, Song WG^#，Wang Q, Wang C, Liu X, Chen D, Zhu Z, Wu Y, Zhang W, Zhang M.Murine Myeloid Dendritic Cells That Phagocytose Apoptotic T Cells Inhibit the Immune Response via NO. PLoS ONE. 2012;7(11):e49378.

15. Xu YP, He H, Li C, Shi Y, Wang Q, Li W, and Song WG*. Immunosuppressive effect of progesterone on dendritic cells in mice. J Reprod Immunol, 2011, 91:17-23.

16. Bai B^#, Song WG^#，Ji YW, Liu X, Tian L, Wang C, Chen DW, Zhang XN, Zhang MH. Microglia and microglia-like cell differentiated from DC inhibit CD4 T cell proliferation. PLoS ONE, 2009, 4(11): e7869.

17. Wei P, Bai L, Song W,Hao G. Characterization of two soil metagenome-derived lipases with high specificity for p-nitrophenyl palmitate. Arch Microbiol, 2009, 191(3): 233-240.

18. Bai B, Tang J, Liu H, Chen J, Li Y, Song W.  Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway. Acta Biochim Biophys Sin, 2008, 40(4):311-318.

19. Li Y, Qu X, Yang H, Kang L, Xu Y, Bai B, Song W*. Bifidobacteria DNA induces murine macrophages activation in vitro. Cell Mol Immunol, 2005, 2(6):473-478.

20. Zhang M, Tang H, Guo Z, An H, Zhu X, Song W, Guo J, Huang X, Chen T, Wang J, Cao X. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells.Nature Immunology, 2004, 5(11):1124-1133.

21.Yu Y, Liu S, Wang W, Song W, Zhang M, Zhang W, Qin Z, Cao X. Involvement of tumour necrosis factor-alpha-related apoptosis inducing ligand in enhanced cytotoxicity of lipopolysaccharide stimulated dendritic cells to activated T cells. Immunology, 2002, 106(3):308-315.

22. Song WG, Liu SX, Qu X, Yu Y, He.L, Wang W,Zhang MH, Cao XT.The biological characteristics of adenovirus-mediated IL-18 gene-modified murine colorectal adenocarcinoma cell. Chinese Journal of Cancer Research,2001;13(3):162-165.

23. Ju DW, Yang Y, Tao Q, Song WG, He L, Chen G, Gu S, Ting CC, Cao X. IL-18 gene transfer increases antitumor effects of suicide gene therapy through efficient induction of antitumor immunity. Gene Therapy, 2000, 7(19):1672-1679. 

三、主持科研项目